Публикации

@article{nokey,

title = {Metal-peptide complexes with antimicrobial potential for cotton fibres protection.},

author = {Stela Georgieva and Petar Todorov and Desislava Staneva and Petar Grozdanov and Ivanka Nikolova and Ivo Grabchev},

url = {http://antiviraltextile.eu/wp-content/uploads/2023/03/jfb-14-00106.pdf

https://www.mdpi.com/2079-4983/14/2/106},

doi = {https://doi.org/10.3390/jfb14020106},

year  = {2023},

date = {2023-02-14},

journal = {Journal of Functional Biomaterials},

volume = {14(2)},

issue = {106},

abstract = {A study of the formation of copper (II) complexes with hemorphin peptide motifs in alkalic

water solutions is presented. The effect of the peptide ligand on the complexing properties of the Cu

(II) ion was quantified by giving the stoichiometry and stability of the complex compounds in the

medium in which they are formed using voltammetric (cyclic) and spectral (UV-Vis and fluorimetric)

analytical techniques. The resulting complexes were examined via IR spectroscopy to detect M-N

and M-O oscillations and using the EPR approach in solution and in the solid phase to view the

coordination and ligand binding regime. The possibility of the synergistic action of copper ions

in the antivirus protection processes of cotton fibers coated in the same solvent with the newly

obtained complex compounds was also investigated. One of the advantages is the formation of the

complexes in an environment where the immobilization takes place, which contributes to increasing

the efficiency of the process. The obtained results may serve as an aid for future more detailed

biological studies of structure–activity relationships (SARs).

Keywords: peptide; hemorphin; copper–peptide complexes; Cu(II) ions; cotton; antivirus protection},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Metal-peptide complexes with antimicrobial potential for cotton fibres protection. },

author = {Stela Georgieva and Petar Todorov and Desislava Staneva and Petar Grozdanov and Ivanka Nikolova and Ivo Grabchev},

editor = {Dana Maria Copolovici and Robert Vasile Gradinaru},

year  = {2023},

date = {2023-02-14},

journal = {Journal of Functional Biomaterials},

volume = {14},

issue = {2},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Recent synthesis, characterization and pharmacological evaluation of multifunctional hemorphins containing non-natural amino acids with potential biological importance.},

author = {Petar Todorov and Stela Georgieva and Jana Tchekalarova},

editor = {Adriano Mollica},

url = {http://antiviraltextile.eu/wp-content/uploads/2023/03/pharmaceuticals-15-01425-v2.pdf

https://www.mdpi.com/1424-8247/15/11/1425 },

doi = {https://doi.org/10.3390/ ph15111425},

year  = {2022},

date = {2022-11-17},

volume = {2022, 15},

issue = {1425},

abstract = {Abstract: The endogenous hemorphins are bioactive peptides with activity on opioid receptors. They

are extensively studied and summarized in numerous reviews. During the last decade, several

research teams have synthesized, characterized, and pharmacologically evaluated synthetic hemorphin

analogs containing unusual amino acids, D-amino acids, -aminophosphonic acids, and their

derivatives. The present review summarizes the current studies on short-chain synthetic hemorphin

peptide derivates containing non-natural amino acids. This review focuses on the structure–activity

relationship analysis, details on specific methods for their characterization, and the advantage of synthetic

hemorphin analogs compared to endogenous peptides as potent biologically active compounds

with a complex mechanism of action.

Keywords: hemorphins; non-natural amino acids; unusual amino acids; non-proteinogenic amino

acids; biological activity; electrochemical behavior of peptides},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Study of Novel Peptides for Antimicrobial Protection in Solution and on Cotton Fabric},

author = {Todorov, P. and Georgieva, S. and Staneva, D. and Peneva, P. and Grozdanov, P. and Nikolova, I. and Vasileva-Tonkova, E. and Grabchev, I. },

editor = {Hiroyuki Konno and Kenichi Akaji},

doi = {https://doi.org/10.3390/molecules27154770},

issn = {1420-3049},

year  = {2022},

date = {2022-07-26},

journal = {Molecules 2022},

volume = {27(15)},

number = {4770},

abstract = {Some new N- and C-modified biomolecular peptide analogues of both VV-hemorphin-5 and VV-hemorphin-7 with varied amino acids (Cys, Glu, His), 1-adamantanecarboxylic acid, and niacin (nicotinic acid) were synthesized by solid-phase peptide synthesis—Fmoc (9-fluorenylmethoxy-carbonyl) chemistry and were characterized in water solutions with different pH using spectroscopic and electrochemical techniques. Basic physicochemical properties related to the elucidation of the peptide structure at physiological pH have been also studied. The results showed that the interaction of peptide compounds with light and electricity preserves the structural and conformational integrity of the compounds in the solutions. Moreover, textile cotton fibers were modified with the new compounds and the binding of the peptides to the surface of the material was proved by FTIR and SEM analysis. Washing the material with an alkaline soap solution did not show a violation of the modified structure of the cotton. Antiviral activity against the human respiratory syncytial virus (HRSV-S2) and human adenovirus serotype 5 (HAdV-5), the antimicrobial activity against B. cereus and P. aeruginosa used as model bacterial strains and cytotoxic effect of the peptide derivatives and modified cotton textile material has been evaluated. Antimicrobial tests showed promising activity of the newly synthesized compounds against the used Gram-positive and Gram-negative bacteria. The compounds C-V, H-V, AC-V, and AH-V were found slightly more active than NH7C and NCH7. The activity has been retained after the deposition of the compounds on cotton fibers. View Full-Text

Keywords: antimicrobial peptides; hemorphins; cotton fabric; absorption; emission; antiviral activity},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Synthesis of New Modified with Rhodamine B Peptides for Antiviral Protection of Textile Materials},

author = {Petar Todorov and Stela Georgieva and Desislava Staneva and Petia Peneva and Petar Grozdanov and Ivanka Nikolova and Ivo Grabchev},

editor = {Hiroyuki Konno, Kenichi Akaji},

url = {https://www.researchgate.net/publication/355796067_Synthesis_of_New_Modified_with_Rhodamine_B_Peptides_for_Antiviral_Protection_of_Textile_Materials},

doi = {10.3390/molecules26216608},

year  = {2021},

date = {2021-10-31},

urldate = {2021-10-31},

journal = {Molecules},

volume = {26(21)},

number = {6608},

abstract = {Here we report on the synthesis and characterization of three new N-modified analogues of hemorphin-4 with rhodamine B. Modified with chloroacetyl, chloride cotton fabric has been dyed and color coordinates of the obtained textile materials were determined. Antiviral and virucidal activities of both the peptide-rhodamine B compounds and the dyed textile material were studied. Basic physicochemical properties (acid-base behavior, solvent influence, kinetics) related to the elucidation of structural activity of the new modified peptides based on their steric open/closed ring effect were studied. The obtained results lead to the conclusion that in protic solvent with change in pH of the environment, direct control over the dyeing of textiles can be achieved. Both the new hybrid peptide compounds and the modification of functionalized textile materials with these bioactive hemorphins showed virucidal activity against the human respiratory syncytial virus (HRSV-S2) and human adenovirus serotype 5 (HAdV-5) for different time intervals (30 and 60 min) and the most active compound was Rh-3},

keywords = {},

pubstate = {published},

tppubtype = {article}

}